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May 10, 2018 N Engl J Med 2018; 378:1802-1810 DOI: 10.1056/NEJMcp1707928


Caren G. Solomon, M.D., M.P.H., Editor

Essential tremor is characterized by isolated bilateral upper-limb action tremor with a duration of at least 3 years. For essential tremor that is refractory to pharmacotherapy, options include deep-brain stimulation or MRI-guided focused ultrasound thalamotomy.

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Disclosure forms provided by the authors are available with the full text of this article at

Dr. Haubenberger reports receiving devices for use in research studies from Cala Health; and Dr. Hallett, receiving devices for use in research studies from and serving on an unpaid scientific advisory board for Cala Health and holding a patent (US 7,407,478), licensed to Brainsway, for the H-coil. No other potential conflict of interest relevant to this article was reported.

From the Clinical Trials Unit, Office of the Clinical Director (D.H.), and the Human Motor Control Section, Medical Neurology Branch (M.H.), National Institute of Neurological Disorders and Stroke Intramural Research Program, National Institutes of Health, Bethesda, MD.

Address reprint requests to Dr. Hallett at the Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, National Institutes of Health, 9000 Rockville Pike, Bldg. 10, Rm. 7D37, Bethesda, MD 20892-1428, or at Kay Jewelers Infinity Symbol Ring 1/15 ct tw Diamonds 10K White Gold U6Jnz3

Living in Netherlands

What is it like to study in the Netherlands?

Students in the Netherlands are encouraged to be very active. Professors are very approachable and avoid too much formalities. Also, the Netherlands has a big international students’ community which is very friendly and open to other newcomers. Dutch students are approachable and can be perfect party buddies. On top of that, you can always use a bike to go to school, the distances are short, and there’s always some cultural activity going on.

Tuition fees in in the Netherlands

As part of the EU, the Netherlands practices different tuition fees for EU/EEA students and non-EU/EEA students. On average, tuition fees for EU students are about 2,000 EUR/year, while for non-EU students, they start at 6,000 EUR/year.

Still, you should be mindful that the cost of studies is influenced by the type of degree and by the subject area. For example, Master’s programmes are typically more expensive then Bachelor’s programmes, and can reach even 20,000 EUR/year.

Accommodation, housing, food and other expenses

The Netherlands is not the cheapest country in the EU, but the living costs here are not that high either. On average you need a minimum budget of 700-800 EUR/month. Here are some figures that will give you an overall idea about what you can expect in terms of Dutch living costs:

About Netherlands

Interesting facts about the Netherlands

Everybody knows that the Netherlands is the country of tulips and windmills. But did you know that Netherlands is not only big on tulips, but on all flower bulbs? About 80% of the world’s flower bulbs come from the Netherlands.

On a more serious note, Netherlands has a very rich cultural history, as it was the home of painters like Hieronymus Bosch, or Jan Steen, but also of the famous sixteen century scholar Erasmus of Rotterdam.

For those of you who still call the Netherlands Holland, you’re in for a surprise: Holland is actually a region of the Netherlands. This means that not all Dutch people come from Holland, but all Hollanders come from the Netherlands.

The Netherlands is also a monarchy since… forever. Interestingly enough, today’s ruling monarch, King Willem-Alexander, is the first male monarch the country has had in 123 years.

Some other interesting facts that might also influence your stay in the Netherlands that you should know about are:

's-Hertogenbosch (1)

Amsterdam (8)

Apeldoorn (1)

Arnhem (1)

Breda (1)

Delft (3)

Den Haag (5)

Deventer (1)

Eindhoven (6)

Enschede (3)

Groningen (2)

Heerlen (1)

Leeuwarden (3)

Leiden (1)

Maastricht (5)

Nijmegen (2)

Rotterdam (5)

Tilburg (3)

Utrecht (4)

Velp (1)

Venlo (2)

Wageningen (1)

Together with the ISIC Association and British Council IELTS, StudyPortals offers you the chance to receive up to £ 10,000 to expand your horizon and study abroad. We want to ultimately encourage you to study abroad in order to experience and explore new countries, cultures and languages.

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Romania is the ninth largest country of the European Union, has the RON as currency and Bucharest as capital. Member of the former communist block, Romania has transitioned to democracy after the 1989 revolution. It has Romanian as official language, a latin-based language, in spite of the slavic-language majority of the neighbouring countries.
The Netherlands (also known as Holland) was the first non-English-speaking country to offer degrees in English. Therefore, various programmes are taught in English and are very internationally oriented.
Situated in Central Europe, Hungary is one of the most popular touristic destinations in Europe and in the world. If you haven't heard about the famous Balaton lake or the thermal water cave system, you have at least hard of the beauty of its capital Budapest and about the delicious Hungarian cuisine.
From literature to landscape, from innovation to internationalisation, Ireland offers a lot of opportunities in education and research… and the warmest of welcomes from the world’s friendliest nation!
Australia is well known for its warm climate, great beaches and exceptional higher education system. It has strong influences from both Europe and Asia, and with the worlds second highest development index, it is a fantastic place to study!
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Contrary to folk wisdom, most laughter is not about humor

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Laughter is part of the universal human vocabulary. All members of the human species understand it. Unlike English or French or Swahili, we don’t have to learn to speak it. We’re born with the capacity to laugh.

One of the remarkable things about laughter is that it occurs unconsciously. You don’t decide to do it. While we can consciously inhibit it, we don’t consciously produce laughter. That’s why it’s very hard to laugh on command or to fake laughter. (Don’t take my word for it: Ask a friend to laugh on the spot.)

Laughter provides powerful, uncensored insights into our unconscious. It simply bubbles up from within us in certain situations.

Very little is known about the specific brain mechanisms responsible for laughter. But we do know that laughter is triggered by many sensations and thoughts, and that it activates many parts of the body.

When we laugh, we alter our facial expressions and make sounds. During exuberant laughter, the muscles of the arms, legs and trunk are involved. Laughter also requires modification in our pattern of breathing.

We also know that laughter is a message that we send to other people. We know this because we rarely laugh when we are alone (we laugh to ourselves even less than we talk to ourselves).

Laughter is social and contagious. We laugh at the sound of laughter itself. That’s why the Tickle Me Elmo doll is such a success — it makes us laugh and smile.


The first laughter appears at about 3.5 to 4 months of age, long before we’re able to speak. Laughter, like crying, is a way for a preverbal infant to interact with the mother and other caregivers.

Contrary to folk wisdom, most laughter is not about humor; it is about relationships between people. To find out when and why people laugh, I and several undergraduate research assistants went to local malls and city sidewalks and recorded what happened just before people laughed. Over a 10-year period, we studied over 2,000 cases of naturally occurring laughter.

We found that most laughter does not follow jokes. People laugh after a variety of statements such as “Hey John, where ya been?” “Here comes Mary,” “How did you do on the test?” and “Do you have a rubber band?”. These certainly aren’t jokes.

We don’t decide to laugh at these moments. Our brain makes the decision for us. These curious “ha ha ha’s” are bits of social glue that bond relationships.


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